Article
Sequence analysis of hepatitis C virus from patients with relapse after a sustained virological response: relapse or reinfection?
The Journal of infectious diseases - 1 Jan 2014
Hara Koji, Rivera Maria M, Koh Christopher, Demino Mary, Page Sandra, Nagabhyru Pothu Raju, Rehermann Barbara, Liang T Jake, Hoofnagle Jay H, Heller Theo
Abstract excerpt
BACKGROUND: A sustained virological response (SVR) is the major end point of therapy for chronic hepatitis C virus (HCV) infection. Late relapse of infection is rare and poorly characterized. Three of 103 patients with a SVR treated at the National Institutes of Health had late relapse. We evaluated HCV RNA sequences in serum and liver tissue to distinguish relapse from reinfection. METHODS: Per patient, 10-22...
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