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Article

Correction of mutations within the cystic fibrosis transmembrane conductance regulator by site-directed RNA editing.

Proceedings of the National Academy of Sciences of the United States of America - 5 Nov 2013

Montiel-Gonzalez Maria Fernanda, Vallecillo-Viejo Isabel, Yudowski Guillermo A, Rosenthal Joshua J C

Abstract excerpt

Adenosine deaminases that act on RNA are a conserved family of enzymes that catalyze a natural process of site-directed mutagenesis. Biochemically, they convert adenosine to inosine, a nucleotide that is read as guanosine during translation; thus when editing occurs in mRNAs, codons can be recoded and the changes can alter protein function. By removing the endogenous targeting domains from human adenosine...

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Identifiers

PMID: 24108353
DOI: 10.1073/pnas.1306243110
PMCID: PMC3831439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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