Article
Heterologous expression of<i>Streptococcus mutans</i>Cnm in<i>Lactococcus lactis</i>promotes intracellular invasion, adhesion to human cardiac tissues and virulence
3 Jun 2016
Abstract excerpt
In S. mutans, the expression of the surface glycoprotein Cnm mediates binding to extracellular matrix proteins, endothelial cell invasion and virulence in the Galleria mellonella invertebrate model. To further characterize Cnm as a virulence factor, the cnm gene from S. mutans strain OMZ175 was expressed in the non-pathogenic Lactococcus lactis NZ9800 using a nisin-inducible system. Despite the absence of the...
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