Article
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population.
Human genetics - 1 Dec 2013
Dumitrescu Logan, Carty Cara L, Franceschini Nora, Hindorff Lucia A, Cole Shelley A, Bůžková Petra, Schumacher Fredrick R, Eaton Charles B, Goodloe Robert J, Duggan David J, Haessler Jeff, Cochran Barbara, Henderson Brian E, Cheng Iona, Johnson Karen C, Carlson Chris S, Love Shelly-Anne, Brown-Gentry Kristin, Nato Alejandro Q, Quibrera Miguel, Shohet Ralph V, Ambite José Luis, Wilkens Lynne R, Le Marchand Loïc, Haiman Christopher A, Buyske Steven, Kooperberg Charles, North Kari E, Fornage Myriam, Crawford Dana C
Abstract excerpt
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over...
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