Article
Evidence for a role of sterol 27-hydroxylase in glucocorticoid metabolism in vivo.
The Journal of endocrinology - 1 Nov 2013
Vögeli Isabelle, Jung Hans H, Dick Bernhard, Erickson Sandra K, Escher Robert, Funder John W, Frey Felix J, Escher Geneviève
Abstract excerpt
The intracellular availability of glucocorticoids is regulated by the enzymes 11β-hydroxysteroid dehydrogenase 1 (HSD11B1) and 11β-hydroxysteroid dehydrogenase 2 (HSD11B2). The activity of HSD11B1 is measured in the urine based on the (tetrahydrocortisol+5α-tetrahydrocortisol)/tetrahydrocortisone ((THF+5α-THF)/THE) ratio in humans and the...
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