Article
Prediction of human disease genes by human-mouse conserved coexpression analysis.
PLoS computational biology - 28 Mar 2008
Ala Ugo, Piro Rosario Michael, Grassi Elena, Damasco Christian, Silengo Lorenzo, Oti Martin, Provero Paolo, Di Cunto Ferdinando
Abstract excerpt
BACKGROUND: Even in the post-genomic era, the identification of candidate genes within loci associated with human genetic diseases is a very demanding task, because the critical region may typically contain hundreds of positional candidates. Since genes implicated in similar phenotypes tend to share very similar expression profiles, high throughput gene expression data may represent a very important resource to...
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