Article
Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects.
British journal of cancer - 29 Oct 2013
Henry N L, Chan H-P, Dantzer J, Goswami C P, Li L, Skaar T C, Rae J M, Desta Z, Khouri N, Pinsky R, Oesterreich S, Zhou C, Hadjiiski L, Philips S, Robarge J, Nguyen A T, Storniolo A M, Flockhart D A, Hayes D F, Helvie M A, Stearns V
Abstract excerpt
BACKGROUND: Change in breast density may predict outcome of women receiving adjuvant hormone therapy for breast cancer. We performed a prospective clinical trial to evaluate the impact of inherited variants in genes involved in oestrogen metabolism and signalling on change in mammographic percent density (MPD) with aromatase inhibitor (AI) therapy. METHODS: Postmenopausal women with breast cancer who were...
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