Article
Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru.
Scientific reports - 30 Sept 2013
Akinyi Sheila, Hayden Tonya, Gamboa Dionicia, Torres Katherine, Bendezu Jorge, Abdallah Joseph F, Griffing Sean M, Quezada Wilmer Marquiño, Arrospide Nancy, De Oliveira Alexandre Macedo, Lucas Carmen, Magill Alan J, Bacon David J, Barnwell John W, Udhayakumar Venkatachalam
Abstract excerpt
The majority of malaria rapid diagnostic tests (RDTs) detect Plasmodium falciparum histidine-rich protein 2 (PfHRP2), encoded by the pfhrp2 gene. Recently, P. falciparum isolates from Peru were found to lack pfhrp2 leading to false-negative RDT results. We hypothesized that pfhrp2-deleted parasites in Peru derived from a single genetic event. We evaluated the parasite population structure and pfhrp2 haplotype of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.