Article
Genetic variation in the serotonin transporter and HTR1B receptor predicts reduced bone formation during serotonin reuptake inhibitor treatment in older adults.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Jul 2014
Garfield Lauren D, Müller Daniel J, Kennedy James L, Mulsant Benoit H, Reynolds Charles F, Teitelbaum Steven L, Civitelli Roberto, Dixon David, Todorov Alexandre A, Lenze Eric J
Abstract excerpt
OBJECTIVES: Studies have reported an association between serotonin reuptake inhibitors (SRIs) and accelerated bone loss. Genetic variation in the serotonin system might modulate bone metabolism changes during SRI treatment. In a clinical trial we examined functional genetic polymorphisms of serotonin transporter and receptors involved in bone metabolism to determine whether they predict changes in bone metabolism...
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