Article
An absolute risk model to identify individuals at elevated risk for pancreatic cancer in the general population.
PloS one - 1 Jan 2013
Klein Alison P, Lindström Sara, Mendelsohn Julie B, Steplowski Emily, Arslan Alan A, Bueno-de-Mesquita H Bas, Fuchs Charles S, Gallinger Steven, Gross Myron, Helzlsouer Kathy, Holly Elizabeth A, Jacobs Eric J, Lacroix Andrea, Li Donghui, Mandelson Margaret T, Olson Sara H, Petersen Gloria M, Risch Harvey A, Stolzenberg-Solomon Rachael Z, Zheng Wei, Amundadottir Laufey, Albanes Demetrius, Allen Naomi E, Bamlet William R, Boutron-Ruault Marie-Christine, Buring Julie E, Bracci Paige M, Canzian Federico, Clipp Sandra, Cotterchio Michelle, Duell Eric J, Elena Joanne, Gaziano J Michael, Giovannucci Edward L, Goggins Michael, Hallmans Göran, Hassan Manal, Hutchinson Amy, Hunter David J, Kooperberg Charles, Kurtz Robert C, Liu Simin, Overvad Kim, Palli Domenico, Patel Alpa V, Rabe Kari G, Shu Xiao-Ou, Slimani Nadia, Tobias Geoffrey S, Trichopoulos Dimitrios, Van Den Eeden Stephen K, Vineis Paolo, Virtamo Jarmo, Wactawski-Wende Jean, Wolpin Brian M, Yu Herbert, Yu Kai, Zeleniuch-Jacquotte Anne, Chanock Stephen J, Hoover Robert N, Hartge Patricia, Kraft Peter
Abstract excerpt
PURPOSE: We developed an absolute risk model to identify individuals in the general population at elevated risk of pancreatic cancer. PATIENTS AND METHODS: Using data on 3,349 cases and 3,654 controls from the PanScan Consortium, we developed a relative risk model for men and women of European ancestry based on non-genetic and genetic risk factors for pancreatic cancer. We estimated absolute risks based on these...
Read the complete abstract on PubMed