Article
Increases in CSF dopamine in HIV patients are due to the dopamine transporter 10/10-repeat allele which is more frequent in HIV-infected individuals.
Journal of neural transmission (Vienna, Austria : 1996) - 1 Oct 2013
Horn Anne, Scheller Carsten, du Plessis Stefan, Arendt Gabriele, Nolting Thorsten, Joska John, Sopper Sieghart, Maschke Matthias, Obermann Mark, Husstedt Ingo W, Hain Johannes, Maponga Tongai, Riederer Peter, Koutsilieri Eleni
Abstract excerpt
Dysfunction of dopaminergic neurotransmission has been implicated in HIV infection. We showed previously increased dopamine (DA) levels in CSF of therapy-naïve HIV patients and an inverse correlation between CSF DA and CD4 counts in the periphery, suggesting adverse effects of high levels of DA on HIV infection. In the current study including a total of 167 HIV-positive and negative donors from Germany and South...
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