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Article

DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas

21 Sept 2013

Abstract excerpt

PURPOSE: Oncolytic viruses (OV) based on herpes simplex virus type 1 (HSV1) are being used in clinical trials for a variety of cancers. The OV, rQNestin34.5, uses a nestin promoter/enhancer to selectively drive robust viral replication in malignant glioma cells. We have discovered that this promoter becomes extensively methylated in infected glioma cells, reducing OV efficacy. EXPERIMENTAL DESIGN: We used...

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PMID: 24056786
DOI: 10.1158/1078-0432.ccr-12-3588

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