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Article

Endogenous glucocorticoid receptor signaling drives rhythmic changes in human T‐cell subset numbers and the expression of the chemokine receptor CXCR4

19 Sept 2013

Abstract excerpt

In humans, numbers of circulating naive T cells strongly decline in the morning, which was suggested to be mediated by cortisol, inducing a CXCR4 up-regulation with a subsequent extravasation of the cells. As a systematic evaluation of this assumption is lacking, we investigated in two human placebo-controlled studies the effects of the glucocorticoid receptor (GR) antagonist mifepristone (200 mg orally at 23:00)...

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PMID: 24051033
DOI: 10.1096/fj.13-237958

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