Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E.

doi:10.1186/1478-811X-11-67

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Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E.

Cell communication and signaling : CCS - 18 Sept 2013

Zhang Zhenzhen, Gong Yuehua, Guo Ying, Hai Yanan, Yang Hao, Yang Shi, Liu Yang, Ma Meng, Liu Linhong, Li Zheng, Gao Wei-Qiang, He Zuping

Abstract excerpt

BACKGROUND: Severe shortage of liver donors and hepatocytes highlights urgent requirement of extra-liver and stem cell source of hepatocytes for treating liver-related diseases. Here we hypothesized that spermatogonial stem cells (SSCs) can directly transdifferentiate to hepatic stem-like cells capable of differentiating into mature hepatocyte-like cells in vitro without an intervening pluripotent state. RESULTS:...

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Direct transdifferentiation of spermatogonial stem cells to morphological, phenotypic and functional hepatocyte-like cells via the ERK1/2 and Smad2/3 signaling pathways and the inactivation of cyclin A, cyclin B and cyclin E.

Abstract excerpt

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