Article
Large solid-pseudopapillary neoplasm of the pancreas with aberrant protein expression and mutation of β-catenin: a case report and literature review of the distribution of β-catenin mutation.
Internal medicine (Tokyo, Japan) - 1 Jan 2013
Kobayashi Takahiko, Ozasa Mariko, Miyashita Kencho, Saga Akiyoshi, Miwa Kimiaki, Saito Makoto, Morioka Masanobu, Takeuchi Motoya, Takenouchi Nobuo, Yabiku Takashi, Kanno Hiromi, Yuzawa Sayaka, Tanino Mishie, Tanaka Shinya, Kawakami Hiroshi, Asaka Masahiro, Sakamoto Naoya
Abstract excerpt
Solid-pseudopapillary neoplasms (SPN) are rare pancreatic tumors. The etiology of SPN involves mutations in the gene that encodes β-catenin (CTNNB1). We herein report the case of a 23-year-old woman with a large SPN with proliferating tumor cells that displayed both solid and pseudo-papillary patterns. The simultaneous nuclear accumulation and loss of membrane localization of β-catenin and E-cadherin was...
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