When to Consider Lynch Syndrome in Non-Colon and Non-Endometrial Malignancies.

doi:10.1177/00031348211031835

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Article

When to Consider Lynch Syndrome in Non-Colon and Non-Endometrial Malignancies.

The American surgeon - 1 May 2023

Arroyave Aaron J, Good Alan W, Ward Andrew J, Orucevic Amila L, McLoughlin James M

Abstract excerpt

Lynch syndrome (LS) is a common genetic syndrome characterized by pathogenic mutations of DNA mismatch repair genes resulting in a hereditary predisposition to cancer. While typically associated with colonic and endometrial cancer, LS additionally influences the development of many other malignancies. The Amsterdam II and Revised Bethesda Guidelines are the established clinical criteria for diagnosing LS. These...

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PMID: 34247540
DOI: 10.1177/00031348211031835

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