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Article

Coordination of fungal biofilm development by extracellular vesicle cargo.

Nature communications - 29 Oct 2021

Zarnowski Robert, Noll Andrea, Chevrette Marc G, Sanchez Hiram, Jones Ryley, Anhalt Hanna, Fossen Jen, Jaromin Anna, Currie Cameron, Nett Jeniel E, Mitchell Aaron, Andes David R

Abstract excerpt

The fungal pathogen Candida albicans can form biofilms that protect it from drugs and the immune system. The biofilm cells release extracellular vesicles (EVs) that promote extracellular matrix formation and resistance to antifungal drugs. Here, we define functions for numerous EV cargo proteins in biofilm matrix assembly and drug resistance, as well as in fungal cell adhesion and dissemination. We use a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34716343
DOI: 10.1038/s41467-021-26525-z
PMCID: PMC8556236

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