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Article

Early developmental emergence of human amygdala-prefrontal connectivity after maternal deprivation.

Proceedings of the National Academy of Sciences of the United States of America - 24 Sept 2013

Gee Dylan G, Gabard-Durnam Laurel J, Flannery Jessica, Goff Bonnie, Humphreys Kathryn L, Telzer Eva H, Hare Todd A, Bookheimer Susan Y, Tottenham Nim

Abstract excerpt

Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivation. Previously institutionalized youths, who experienced early maternal deprivation, exhibited...

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Identifiers

PMID: 24019460
DOI: 10.1073/pnas.1307893110
PMCID: PMC3785723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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