Article
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2013
Kelly Tanika N, Takeuchi Fumihiko, Tabara Yasuharu, Edwards Todd L, Kim Young Jin, Chen Peng, Li Huaixing, Wu Ying, Yang Chi-Fan, Zhang Yonghong, Gu Dongfeng, Katsuya Tomohiro, Ohkubo Takayoshi, Gao Yu-Tang, Go Min Jin, Teo Yik Ying, Lu Ling, Lee Nanette R, Chang Li-Ching, Peng Hao, Zhao Qi, Nakashima Eitaro, Kita Yoshikuni, Shu Xiao-Ou, Kim Nam Hee, Tai E Shyong, Wang Yiqin, Adair Linda S, Chen Chien-Hsiun, Zhang Shihiu, Li Changwei, Nabika Toru, Umemura Satoshi, Cai Qiuyin, Cho Yoon Shin, Wong Tien Yin, Zhu Jingwen, Wu Jer-Yuarn, Gao Xin, Hixson James E, Cai Hui, Lee Juyoung, Cheng Ching-Yu, Rao Dabeeru C, Xiang Yong-Bing, Cho Myeong-Chan, Han Bok-Ghee, Wang Aili, Tsai Fuu-Jen, Mohlke Karen, Lin Xu, Ikram Mohammad Kamran, Lee Jong-Young, Zheng Wei, Tetsuro Miki, Kato Norihiro, He Jiang
Abstract excerpt
We conducted a genome-wide association study meta-analysis of mean arterial pressure and pulse pressure among 26,600 East Asian participants (stage 1) followed by replication study of up to 28,783 participants (stage 2). For novel loci, statistical significance was determined by a P<5.0×10(-8) in joint analysis of stage 1 and stage 2 data. For loci reported by the previous mean arterial and pulse pressure...
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