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Article

A phenotypic compound screening assay for lysosomal storage diseases.

Journal of biomolecular screening - 1 Jan 2014

Xu Miao, Liu Ke, Swaroop Manju, Sun Wei, Dehdashti Seameen J, McKew John C, Zheng Wei

Abstract excerpt

The lysosome is a vital cellular organelle that primarily functions as a recycling center for breaking down unwanted macromolecules through a series of hydrolases. Functional deficiencies in lysosomal proteins due to genetic mutations have been found in more than 50 lysosomal storage diseases that exhibit characteristic lipid/macromolecule accumulation and enlarged lysosomes. Recently, the lysosome has emerged as...

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Identifiers

PMID: 23983233
DOI: 10.1177/1087057113501197
PMCID: PMC4818652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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