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Article

A molecular switch in the efficiency of translation reinitiation controls expression of var2csa , a gene implicated in pregnancy‐associated malaria

28 Aug 2013

Abstract excerpt

Plasmodium falciparum malaria parasites export the protein PfEMP1 to the surface of infected erythrocytes, enabling them to adhere to receptors in the microvasculature and thereby avoid clearance by the spleen. The gene var2csa encodes the form of PfEMP1 that binds specifically within the placenta, causing pregnancy-associated malaria, and appears to not be expressed in the absence of a placenta. We previously...

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PMID: 23980802
DOI: 10.1111/mmi.12379

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