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Article

Immune mechanisms in polymyositis and dermatomyositis and potential targets for therapy

22 Aug 2013

Abstract excerpt

PM and DM are characterized clinically by weakness and low endurance of skeletal muscle. Other organs are frequently involved, suggesting that idiopathic inflammatory myopathies (IIMs) are systemic inflammatory diseases. Involvement of immune mechanisms in IIMs is supported by the presence of T cells, macrophages and dendritic cells in muscle tissue, by the presence of autoantibodies and by HLA-DR being a strong...

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PMID: 23970542
DOI: 10.1093/rheumatology/ket279

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