Article
Association of circulating levels of nicotinamide phosphoribosyltransferase (NAMPT/Visfatin) and of a frequent polymorphism in the promoter of the NAMPT gene with coronary artery disease in diabetic and non-diabetic subjects.
Cardiovascular diabetology - 22 Aug 2013
Saddi-Rosa Pedro, Oliveira Carolina, Crispim Felipe, Giuffrida Fernando M A, de Lima Valter, Vieira José, Doria Alessandro, Velho Gilberto, Reis André
Abstract excerpt
BACKGROUND: Nicotinamide phosphoribosyltransferase (NAMPT) is the limiting enzyme in one of pathways of synthesis of Nicotinamide Adenine Dinucleotide, a redox coenzyme. NAMPT is considered as an insulin-mimetic factor and a potential regulatory factor in inflammatory and immune processes. Associations of circulating NAMPT levels with cardiovascular disease (CVD) and insulin resistance have been reported. We...
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