Article
A semi-quantitative model of Quorum-Sensing in Staphylococcus aureus, approved by microarray meta-analyses and tested by mutation studies.
Molecular bioSystems - 1 Nov 2013
Audretsch Christof, Lopez Daniel, Srivastava Mugdha, Wolz Christiane, Dandekar Thomas
Abstract excerpt
Staphylococcus aureus (SA) causes infections including severe sepsis by antibiotic-resistant strains. It forms biofilms to protect itself from the host and antibiotics. Biofilm and planktonic lifestyle are regulated by a complex quorum sensing system (QS) with the central regulator agr. To study...
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