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Mitochondrial Quality Control Strategies: Potential Therapeutic Targets for Neurodegenerative Diseases?

12 Nov 2021

Abstract excerpt

Many lines of evidence have indicated the therapeutic potential of rescuing mitochondrial integrity by targeting specific mitochondrial quality control pathways in neurodegenerative diseases, such as Parkinson's disease, Huntington's disease, and Alzheimer's disease. In addition to ATP synthesis, mitochondria are critical regulators of ROS production, lipid metabolism, calcium buffering, and cell death. The...

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PMID: 34867159
DOI: 10.3389/fnins.2021.746873

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