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Article

Analysis of the dominant effects mediated by wild type or R120G mutant of αB-crystallin (HspB5) towards Hsp27 (HspB1).

PloS one - 1 Jan 2013

Simon Stéphanie, Dimitrova Valeriya, Gibert Benjamin, Virot Sophie, Mounier Nicole, Nivon Mathieu, Kretz-Remy Carole, Corset Véronique, Mehlen Patrick, Arrigo André-Patrick

Abstract excerpt

Several human small heat shock proteins (sHsps) are phosphorylated oligomeric chaperones that enhance stress resistance. They are characterized by their ability to interact and form polydispersed hetero-oligomeric complexes. We have analyzed the cellular consequences of the stable expression of either wild type HspB5 or its cataracts and myopathies inducing R120G mutant in growing and oxidative stress treated...

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Identifiers

PMID: 23950959
DOI: 10.1371/journal.pone.0070545
PMCID: PMC3741289

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