Article
ERManI is a target of miR-125b and promotes transformation phenotypes in hepatocellular carcinoma (HCC).
PloS one - 1 Jan 2013
Pan Shujuan, Cheng Xiaoyun, Chen Hongan, Castro Patricia D, Ittmann Michael M, Hutson Anne W, Zapata Susan K, Sifers Richard N
Abstract excerpt
The MAN1B1 gene product, designated ER alpha-1, 2-mannosidase (ERManI), is an enzyme localized in the Golgi complex of mammalian cells. By functioning as a "gate keeper" to prevent the inappropriate secretion of misfolded glycoproteins, it plays a critical role in maintaining protein homeostasis in the mammalian secretory pathway. In the present study, we identified that a conserved motif within the 3'UTR of...
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