Article
The single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene influences endothelial cell function: interaction with selenium and fatty acids.
Molecular nutrition & food research - 1 Dec 2013
Crosley Lynne K, Bashir Shabina, Nicol Fergus, Arthur John R, Hesketh John E, Sneddon Alan A
Abstract excerpt
SCOPE: Selenium (Se) is incorporated into selenoproteins as selenocysteine, which requires structures in the 3'-untranslated region (3'-UTR) of selenoprotein mRNAs. The functional consequences of a single nucleotide polymorphism (SNP) within the 3'-UTR of the selenoprotein GPX4 gene (GPX4c718t) was assessed in human umbilical vein endothelial cells (HUVECs) and monocytes from human volunteers. METHODS AND...
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