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Article

A Gene-Specific Method for Predicting Hemophilia-Causing Point Mutations

3 Aug 2013

Abstract excerpt

A fundamental goal of medical genetics is the accurate prediction of genotype-phenotype correlations. As an approach to develop more accurate in silico tools for prediction of disease-causing mutations of structural proteins, we present a gene- and disease-specific prediction tool based on a large systematic analysis of missense mutations from hemophilia A (HA) patients. Our HA-specific prediction tool,...

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PMID: 23920358
DOI: 10.1016/j.jmb.2013.07.037

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