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Article

Association of paraoxonase 1 gene polymorphism and enzyme activity with carotid plaque in rheumatoid arthritis.

Arthritis and rheumatism - 1 Nov 2013

Charles-Schoeman Christina, Lee Yuen Yin, Shahbazian Ani, Gorn Alan H, Fitzgerald John, Ranganath Veena K, Taylor Mihaela, Ragavendra Nagesh, McMahon Maureen, Elashoff David, Reddy Srinivasa T

Abstract excerpt

OBJECTIVE: To investigate the relationship of genetic and biochemical determinants of paraoxonase 1 activity to carotid plaque as a surrogate marker of cardiovascular (CV) risk in patients with rheumatoid arthritis (RA). METHODS: The relationships between paraoxonase 1 activity, PON1 genotype (for the functional polymorphism at position 192), and carotid plaque presence were determined in 168 RA patients. After...

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Identifiers

PMID: 23917967
DOI: 10.1002/art.38118
PMCID: PMC4410876

Genes

PON1

Variants

Provenance

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