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Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1

5 Aug 2013

Abstract excerpt

BACKGROUND: Viral protein R (Vpr), a protein of human immunodeficiency virus type-1 (HIV-1) with various biological functions, was shown to be present in the blood of HIV-1-positive patients. However, it remained unclear whether circulating Vpr in patients' blood is biologically active. Here, we examined the activity of blood Vpr using an assay system by which retrotransposition of long interspersed element-1...

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PMID: 23915234
DOI: 10.1186/1742-4690-10-83

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