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Article

Automated identification of functional dynamic contact networks from X-ray crystallography.

Nature methods - 1 Sept 2013

van den Bedem Henry, Bhabha Gira, Yang Kun, Wright Peter E, Fraser James S

Abstract excerpt

Protein function often depends on the exchange between conformational substates. Allosteric ligand binding or distal mutations can stabilize specific active-site conformations and consequently alter protein function. Observing alternative conformations at low levels of electron density, in additi...

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Identifiers

PMID: 23913260
DOI: 10.1038/nmeth.2592
PMCID: PMC3760795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23913260-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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