Article
[The application of multiplex ligation-dependent probe amplification technology in diagnosis and prenatal diagnosis of α-thalassemia].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi - 1 Jul 2013
Chen Ya-jun, Yang Xue-huang, Zeng Xian-qi, Qiao Ling-li
Abstract excerpt
OBJECTIVE: To investigate the multiplex ligation-dependent probe amplification (MLPA) technology in the detection of gene deletion and prenatal diagnosis of α-thalassaemia. METHODS: Phenotypes were analyzed by whole blood cell counting and hemoglobin component detection of peripheral blood samples from the subjects. The gene deletions and point mutations of α- thalassaemia were detected with regular gap-PCR and...
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