Article
Characterization of alpha thalassemic genotypes by multiplex ligation-dependent probe amplification in the Brazilian population.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2011
Suemasu C N, Kimura E M, Oliveira D M, Bezerra M A C, Araújo A S, Costa F F, Sonati M F
Abstract excerpt
Alpha-thalassemia is the most common inherited disorder of hemoglobin synthesis. Genomic deletions involving the alpha-globin gene cluster on chromosome 16p13.3 are the most frequent molecular causes of the disease. Although common deletions can be detected by a single multiplex gap-PCR, the rare and novel deletions depend on more laborious techniques for their identification. The multiplex ligation-dependent...
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