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Article

A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.

Molecular and cellular biology - 1 Sept 1990

Wilson D B, Dorfman D M, Orkin S H

Abstract excerpt

Endothelin-1 (ET-1) is a 21-amino-acid peptide synthesized by endothelial cells that has potent vasoconstrictor activity. Human ET-1 is derived from a 212-amino-acid prepropeptide, termed preproendothelin-1 (PPET-1). To identify cis-acting sequences essential for PPET-1 gene transcription, bovine aortic endothelial (BAE) cells were transfected with plasmids containing 5'-flanking sequences of the human PPET-1...

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Identifiers

PMID: 2388628
DOI: 10.1128/mcb.10.9.4854-4862.1990
PMCID: PMC361096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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