A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.

doi:10.1128/mcb.10.9.4854-4862.1990

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Article

A nonerythroid GATA-binding protein is required for function of the human preproendothelin-1 promoter in endothelial cells.

Molecular and cellular biology - 1 Sept 1990

Wilson D B, Dorfman D M, Orkin S H

Abstract excerpt

Endothelin-1 (ET-1) is a 21-amino-acid peptide synthesized by endothelial cells that has potent vasoconstrictor activity. Human ET-1 is derived from a 212-amino-acid prepropeptide, termed preproendothelin-1 (PPET-1). To identify cis-acting sequences essential for PPET-1 gene transcription, bovine aortic endothelial (BAE) cells were transfected with plasmids containing 5'-flanking sequences of the human PPET-1...

Topics

Animals
Base Sequence
Bromodeoxyuridine
Cattle
Cell Line
Cell Nucleus
Cells, Cultured
Cross-Linking Reagents
DNA-Binding Proteins
Endothelin-1
Endothelium, Vascular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HeLa Cells

Humans

Molecular Sequence Data

Mutation

Peptides

Plasmids

Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 2388628
DOI: 10.1128/mcb.10.9.4854-4862.1990
PMCID: PMC361096

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2388628-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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