In vitro fabrication of autologous living tissue-engineered vascular grafts based on prenatally harvested ovine amniotic fluid-derived stem cells.

doi:10.1002/term.1781

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In vitro fabrication of autologous living tissue-engineered vascular grafts based on prenatally harvested ovine amniotic fluid-derived stem cells.

Journal of tissue engineering and regenerative medicine - 1 Jan 2016

Weber Benedikt, Kehl Debora, Bleul Ulrich, Behr Luc, Sammut Sébastien, Frese Laura, Ksiazek Agnieszka, Achermann Josef, Stranzinger Gerald, Robert Jérôme, Sanders Bart, Sidler Michele, Brokopp Chad E, Proulx Steven T, Frauenfelder Thomas, Schoenauer Roman, Emmert Maximilian Y, Falk Volkmar, Hoerstrup Simon P

Abstract excerpt

Amniotic fluid cells (AFCs) have been proposed as a valuable source for tissue engineering and regenerative medicine. However, before clinical implementation, rigorous evaluation of this cell source in clinically relevant animal models accepted by regulatory authorities is indispensable. Today, the ovine model represents one of the most accepted preclinical animal models, in particular for cardiovascular...

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PMID: 23881794
DOI: 10.1002/term.1781

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