Article
Living autologous heart valves engineered from human prenatally harvested progenitors.
Circulation - 4 Jul 2006
Schmidt Dörthe, Mol Anita, Breymann Christian, Achermann Josef, Odermatt Bernhard, Gössi Matthias, Neuenschwander Stefan, Prêtre René, Genoni Michele, Zund Gregor, Hoerstrup Simon P
Abstract excerpt
BACKGROUND: Heart valve tissue engineering is a promising strategy to overcome the lack of autologous growing replacements, particularly for the repair of congenital malformations. Here, we present a novel concept using human prenatal progenitor cells as new and exclusive cell source to generate autologous implants ready for use at birth. METHODS AND RESULTS: Human fetal mesenchymal progenitors were isolated from...
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