Article
Local exome sequences facilitate imputation of less common variants and increase power of genome wide association studies.
PloS one - 1 Jan 2013
Joshi Peter K, Prendergast James, Fraser Ross M, Huffman Jennifer E, Vitart Veronique, Hayward Caroline, McQuillan Ruth, Glodzik Dominik, Polašek Ozren, Hastie Nicholas D, Rudan Igor, Campbell Harry, Wright Alan F, Haley Chris S, Wilson James F, Navarro Pau
Abstract excerpt
The analysis of less common variants in genome-wide association studies promises to elucidate complex trait genetics but is hampered by low power to reliably detect association. We show that addition of population-specific exome sequence data to global reference data allows more accurate imputation, particularly of less common SNPs (minor allele frequency 1-10%) in two very different European populations. The...
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