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Article

Gefitinib enhances cytotoxicities of antimicrotubule agents in non-small-cell lung cancer cells exhibiting no sensitizing epidermal growth factor receptor mutation.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Aug 2012

Tsai Chun-Ming, Chiu Chao-Hua, Chang Kao-Ting, Chen Jen-Ting, Lai Chun-Liang, Chen Yuh-Min, Hsiao Shih-Yin

Abstract excerpt

INTRODUCTIONS: Although randomized clinical trials showed no benefit from combining epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) with standard chemotherapy for advanced non-small-cell lung cancer (NSCLC), better results might be obtained by combining EGFR-TKI with individual agents that are substrates for the adenosine triphosphate binding cassette transporters (ABCTs) because...

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Identifiers

PMID: 22659964
DOI: 10.1097/JTO.0b013e318258cf17

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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