Article
Facial pain with localized and widespread manifestations: separate pathways of vulnerability.
Pain - 1 Nov 2013
Slade Gary D, Smith Shad B, Zaykin Dmitri V, Tchivileva Inna E, Gibson Dustin G, Yuryev Anton, Mazo Ilya, Bair Eric, Fillingim Roger, Ohrbach Richard, Greenspan Joel, Maixner William, Diatchenko Luda
Abstract excerpt
Human association studies of common genetic polymorphisms have identified many loci that are associated with risk of complex diseases, although individual loci typically have small effects. However, by envisaging genetic associations in terms of cellular pathways, rather than any specific polymorphism, combined effects of many biologically relevant alleles can be detected. The effects are likely to be most...
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