Article
Tumor necrosis factor alpha and lymphotoxin production in Hodgkin's disease.
The American journal of pathology - 1 Aug 1990
Kretschmer C, Jones D B, Morrison K, Schlüter C, Feist W, Ulmer A J, Arnoldi J, Matthes J, Diamantstein T, Flad H D
Abstract excerpt
It is likely that the characteristic histologic features of Hodgkin's disease reflect cytokine production by the tumor cell population. Tumor necrosis factor alpha (TNF-alpha) and lymphotoxin (tumor necrosis factor beta [TNF-beta]) are important inflammatory mediators with wide-ranging effects within the lymphoreticular system. The aim of the present study was to investigate TNF-alpha and lymphotoxin production...
Topics
- Biopsy
- Cell Division
- Cell Line
- Fibroblasts
- Genotype
- Hodgkin Disease
- Humans
- Lymphotoxin-alpha
- Phenotype
- RNA, Messenger
- Spleen
- Tumor Cells, Cultured