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Article

Tcf19 is a novel islet factor necessary for proliferation and survival in the INS-1 β-cell line

17 Jul 2013

Abstract excerpt

Recently, a novel type 1 diabetes association locus was identified at human chromosome 6p31.3, and transcription factor 19 (TCF19) is a likely causal gene. Little is known about Tcf19, and we now show that it plays a role in both proliferation and apoptosis in insulinoma cells. Tcf19 is expressed in mouse and human islets, with increasing mRNA expression in nondiabetic obesity. The expression of Tcf19 is...

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PMID: 23860123
DOI: 10.1152/ajpendo.00147.2013

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