Article
A mineralocorticoid receptor mutation causing human hypertension.
Current opinion in nephrology and hypertension - 1 Sept 2001
Geller D S
Abstract excerpt
In recent years, the study of monogenic forms of hypertension has added greatly to our understanding of the regulatory mechanisms affecting blood pressure. Recently, a novel such form of human hypertension caused by gain-of-function mutation in the mineralocorticoid receptor, the mediator of aldosterone-induced sodium transport in the distal nephron, has been described, with the notable finding being that...
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