Article
Antimalarial drug targets and drugs targeting dolichol metabolic pathway of Plasmodium falciparum.
Current drug targets - 1 Apr 2014
Qidwai Tabish, Priya Avantika, Khan Nihal Ahmad, Tripathi Himanshu, Khan Feroz, Darokar Mahendra Pandurang, Pal Anirban, Bawankule Dnyneshwar U, Shukla Rakesh Kumar, Bhakuni Rajendra Singh
Abstract excerpt
Because of mutation and natural selection, development of drug resistance to the existing antimalarial is the major problem in malaria treatment. This problem has created an urgent need of novel antimalarial drug targets as well as lead compounds. The important characteristic of malaria is that it shows the phenomenon of balanced polymorphisms. Several traits have been selected in response to disease pressure....
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