Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 Signaling

20 Jun 2013

Abstract excerpt

Resistance to radiation therapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown to contribute to breast tumorigenesis; however, the relationship between Lin28 and radioresistance remains unknown. In this study, we investigated the association of Lin28 with radiation resistance and identified the underlying mechanisms of action of Lin28 in human breast cancer cell lines. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to MicroRNA in disease regulation
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23840685
DOI: 10.1371/journal.pone.0067373

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lin28 Mediates Radiation Resistance of Breast Cancer Cells via Regulation of Caspase, H2A.X and Let-7 SignalingPMID 23840685Read ↗

LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathwaySemantic proximity Read ↗

Let-7 miRNAs sensitize breast cancer stem cells to radiation-induced repression through inhibition of the cyclin D1/Akt1/Wnt1 signaling pathwaySemantic proximity Read ↗

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapySemantic proximity Read ↗

HOXC10 Expression Supports the Development of Chemotherapy Resistance by Fine Tuning DNA Repair in Breast Cancer CellsSemantic proximity Read ↗

The research progress on radiation resistance of cervical cancerSemantic proximity Read ↗

Radiation Resistance of Breast Cancer Stem Cells: Understanding the Clinical FrameworkSemantic proximity Read ↗

The p21-Dependent Radiosensitization of Human Breast Cancer Cells by MLN4924, an Investigational Inhibitor of NEDD8 Activating EnzymeSemantic proximity Read ↗

USP17L2-SIRT7 axis regulates DNA damage repair and chemoresistance in breast cancer cellsSemantic proximity Read ↗

microRNAs in Cancer Cell Response to Ionizing RadiationSemantic proximity Read ↗

Fractionated irradiation of MCF7 breast cancer cells rewires a gene regulatory circuit towards a treatment-resistant stemness phenotype.Semantic proximity Read ↗

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapySemantic proximity Read ↗

The Detection of DNA Damage Response in MCF7 and MDA-MB-231 Breast Cancer Cell Lines after X-ray ExposureSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.