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Article

The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.

Psychoneuroendocrinology - 1 Sept 2013

Daskalakis Nikolaos P, Bagot Rosemary C, Parker Karen J, Vinkers Christiaan H, de Kloet E R

Abstract excerpt

Stressful experiences during early-life can modulate the genetic programming of specific brain circuits underlying emotional and cognitive aspects of behavioral adaptation to stressful experiences later in life. Although this programming effect exerted by experience-related factors is an important determinant of mental health, its outcome depends on cognitive inputs and hence the valence an individual assigns to...

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Identifiers

PMID: 23838101
DOI: 10.1016/j.psyneuen.2013.06.008
PMCID: PMC3773020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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