Article
Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea: a nationwide multicenter study.
Scandinavian journal of infectious diseases - 1 Nov 2013
Kim Ji Hoon, Yeon Jong Eun, Baik Soon Koo, Kim Young Seok, Kim Hong Soo, Park Sang Hoon, Lee Myung-Seok, Sohn Joo Hyun, Lee Jin-Woo, Choi Sung Kyu, Kwon So Young, Choi Jong Young, Kim Ju Hyun, Kang Soon Young, An Hyonggin, Seo Yeon Seok, Yim Hyung Joon, Song Jin-Won, Um Soon Ho, Byun Kwan Soo
Abstract excerpt
BACKGROUND: The genotypic shift of hepatitis A virus (HAV) and its correlation with clinical course has not been evaluated in acute hepatitis A (AHA). METHODS: From June 2007 to May 2009, we prospectively enrolled 546 AHA patients. We performed a nested reverse transcriptase polymerase chain reaction (RT-PCR) using the serum samples in addition to phylogenetic analysis, then we compared patient clinical features....
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