Article
A protein domain-centric approach for the comparative analysis of human and yeast phenotypically relevant mutations.
BMC genomics - 1 Jan 2013
Peterson Thomas A, Park DoHwan, Kann Maricel G
Abstract excerpt
BACKGROUND: The body of disease mutations with known phenotypic relevance continues to increase and is expected to do so even faster with the advent of new experimental techniques such as whole-genome sequencing coupled with disease association studies. However, genomic association studies are limited by the molecular complexity of the phenotype being studied and the population size needed to have adequate...
Topics
- Computational Biology
- Evolution, Molecular
- Genetic Diseases, Inborn
- Humans
- Mutation
- Phenotype
- Protein Structure, Tertiary
- Species Specificity
- Yeasts