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Article

Uptake and intracellular trafficking of superantigens in dendritic cells.

PloS one - 1 Jan 2013

Ganem María B, De Marzi Mauricio C, Fernández-Lynch María J, Jancic Carolina, Vermeulen Mónica, Geffner Jorge, Mariuzza Roy A, Fernández Marisa M, Malchiodi Emilio L

Abstract excerpt

Bacterial superantigens (SAgs) are exotoxins produced mainly by Staphylococcus aureus and Streptococcus pyogenes that can cause toxic shock syndrome (TSS). According to current paradigm, SAgs interact directly and simultaneously with T cell receptor (TCR) on the T cell and MHC class II (MHC-II) on the antigen-presenting cell (APC), thereby circumventing intracellular processing to trigger T cell activation....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23799083
DOI: 10.1371/journal.pone.0066244
PMCID: PMC3682983

Genes

APC
EEA1

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