Article
Peptide-pulsed dendritic cell vaccination targeting interleukin-13 receptor α2 chain in recurrent malignant glioma patients with HLA-A*24/A*02 allele.
Cytotherapy - 1 Jul 2012
Iwami Kenichiro, Shimato Shinji, Ohno Masasuke, Okada Hideho, Nakahara Norimoto, Sato Yuichiro, Yoshida Jun, Suzuki Satoshi, Nishikawa Hiroyoshi, Shiku Hiroshi, Natsume Atsushi, Wakabayashi Toshihiko
Abstract excerpt
BACKGROUND AIMS: Dendritic cell (DC)-based vaccination targeting tumor-associated antigens is an attractive approach to overcoming the limitations of current treatments for malignant gliomas (MG). Interleukin-13 receptor α2 chain (IL-13Rα2) is a promising target because of its abundant and specific expression in MG. We conducted a phase I trial of DC vaccination in patients with recurrent MG using two...
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